Ethics and Law AKP

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1 / 80

Category: Ethics and Law

A 16-year-old boy attends the paediatric research unit. He has been living with Crohn's disease for five years, managed with conventional therapies, but experiences ongoing flare-ups.

He is invited to participate in a clinical trial for a new biological medication, showing enthusiasm for potential symptom improvement. During the screening process, he is assessed by the research team and is deemed to have the capacity to understand the implications of the trial, including potential risks and benefits.

After a thorough explanation of the study protocol, he provides his written consent to enrol. Subsequently, his parents inform the clinical team that they do not consent for their son to participate, citing concerns about experimental drugs.

Which of the following statements most accurately describes the legal position regarding his enrolment?

2 / 80

Category: Ethics and Law

A male infant, born at 25 weeks gestation, is admitted to a tertiary neonatal intensive care unit following spontaneous preterm labour.

The unit is participating in a multi-centre trial comparing two positive end-expiratory pressure (PEEP) strategies for infants born at 25 weeks gestation during delivery room resuscitation.

According to the protocol, each attending consultant is randomly allocated to use either a 'standard' or a 'high' PEEP setting for all resuscitations they manage during the study period.

Which of the following best describes this type of study design?

3 / 80

Category: Ethics and Law

A 7-year-old boy is discussed at a multidisciplinary meeting regarding his potential participation in a proposed randomised controlled trial for a novel therapy for a rare, progressive neurological condition.

He has experienced gradual motor regression over the past 18 months, now requiring significant assistance with mobility and fine motor tasks. On examination, he exhibits generalised hypotonia, brisk reflexes, and mild ataxia; his SpO2 is 98% on air, heart rate 85 bpm, and temperature 37.1 °C.

There is currently no established, effective standard treatment available for his specific condition. A paediatric research ethics committee is reviewing the trial proposal, which involves comparing the new active medication against a placebo.

Which of the following represents the primary ethical justification required for the use of a placebo in this context?

4 / 80

Category: Ethics and Law

A 5-year-old girl attends a follow-up appointment at a paediatric genetics research clinic. She has been a participant in a large-scale genetic research study for the past year, investigating early childhood development.

An incidental finding from her genetic sequencing identifies a pathogenic variant in the BRCA1 gene, which is associated with a high risk of adult-onset cancer. She is otherwise well, with normal growth and development, and there are no recommended screening or therapeutic interventions for this finding during childhood.

Her parents contact the research team and ask for this result to be disclosed to them.

What is the most appropriate response to the parents' request?

5 / 80

Category: Ethics and Law

A 14-year-old girl attends the paediatric research unit for consideration of participation in a non-therapeutic observational study investigating genetic markers for asthma. She has mild intermittent asthma, well-controlled on salbutamol PRN, and has no acute symptoms.

During the consent process, she demonstrates good understanding of the study's aims and risks, and is assessed as having the capacity to assent. Her mother, who holds parental responsibility, provides full written consent. However, her father, who is separated from the mother but also retains parental responsibility, explicitly withholds his consent, stating he does not wish her to participate.

What is the most appropriate action regarding this child's inclusion in the study?

6 / 80

Category: Ethics and Law

A 7-year-old boy with moderate persistent asthma is being considered for a new six-month research study in a tertiary paediatric respiratory clinic. His parents are discussing participation, which involves fortnightly hospital visits for lung function assessments and completing several detailed daily symptom questionnaires.

The study protocol proposes offering a £150 shopping voucher to each family upon completion, in addition to travel reimbursement.

When reviewing the proposed remuneration, what is the primary ethical concern this raises?

7 / 80

Category: Ethics and Law

A Paediatric Registrar on the general paediatric ward is planning a quality improvement project. They aim to retrospectively review the electronic health records of all children, aged 2-16 years, admitted to the hospital with an acute exacerbation of asthma over the last 12 months.

The project's objective is to systematically measure local antibiotic prescribing practice for these admissions against current national guidelines, such as those from NICE or BTS/SIGN, to identify areas for improvement in patient care.

Which of the following correctly classifies this activity and the required governance approval?

8 / 80

Category: Ethics and Law

A 12-year-old boy attends the paediatric research clinic, having been identified as a potential participant in a new vaccine trial for a common respiratory virus. He is a Looked After Child, subject to a full Care Order, and resides in a local authority children's home.

He appears well, is articulate, and expresses interest in understanding the trial. His social worker and children's home manager are present, but his biological parents are not involved in his daily care.

Which body is legally required to provide formal consent for his participation?

9 / 80

Category: Ethics and Law

A 6-year-old boy is brought to the Emergency Department by ambulance with ongoing generalised convulsions for 30 minutes. He is unconscious with a GCS of 3 and continuous tonic-clonic movements. Initial treatment with intravenous lorazepam has failed to terminate the seizure, and he is diagnosed with status epilepticus.

The hospital is participating in a clinical trial for a novel second-line anticonvulsant. His parents are not present and cannot be contacted immediately despite multiple attempts.

What is the most appropriate action regarding his eligibility for the clinical trial?

10 / 80

Category: Ethics and Law

An 8-year-old girl attends her routine annual review at the regional paediatric cystic fibrosis specialist clinic. She has a history of pancreatic insufficient cystic fibrosis and has been stable on her current therapies for the past 18 months, with no recent hospital admissions or significant exacerbations.

Her FEV1 is consistently around 85% predicted. On examination, she is thriving, with a weight on the 50th centile and height on the 75th centile.

Her mother, who holds sole parental responsibility, has provided written informed consent for her participation in a new investigational medicinal product trial. The girl herself was involved in the detailed discussion with the research team and clearly gave her verbal assent to participate.

Considering this, what is the minimum legal requirement to proceed with her enrolment into the clinical trial?

11 / 80

Category: Ethics and Law

A 10-year-old boy attends the paediatric research unit with his parents. He has been invited to participate in a non-therapeutic research study investigating brain development.

The study involves an additional MRI scan, which would take approximately 45 minutes. His parents have provided full written consent for his participation.

During the detailed explanation of the study procedures, including the MRI, the boy clearly states, "I don't want to do it." He appears articulate and understands the information presented.

What is the most appropriate action regarding his inclusion in the study?

12 / 80

Category: Ethics and Law

A 32-year-old woman is attending an antenatal counselling session with the neonatal team. She is 26 weeks of gestation with a monochorionic diamniotic twin pregnancy, complicated by early-onset pre-eclampsia and impending preterm delivery.

The team discusses a randomised controlled trial for a new surfactant, aiming to improve respiratory outcomes. The mother expresses interest in the trial, having researched potential benefits for preterm infants, but states she will only consent if she can be guaranteed that her baby will be allocated to the group receiving the new investigational drug.

What is the most appropriate initial response to her statement?

13 / 80

Category: Ethics and Law

A male neonate, born at 24 weeks of gestation, is managed on the neonatal intensive care unit. Following antenatal counselling, his parents requested full active management.

He required intubation and ventilation at birth but responded to resuscitation and was stabilised. At 48 hours of life, he remains ventilator-dependent with poor tone and minimal spontaneous movements.

A cranial ultrasound scan reveals a bilateral Grade 4 intraventricular haemorrhage with associated parenchymal infarction. The clinical team concludes the neurological prognosis is devastating, anticipating severe neurodevelopmental impairment and significant dependency.

What is the most appropriate next step in this baby's management?

14 / 80

Category: Ethics and Law

A term male infant is delivered in the labour ward. At birth, he is noted to be pale and flaccid, with no discernible heart rate or respiratory effort.

A senior registrar-led neonatal resuscitation team immediately commences full neonatal life support. Despite 20 minutes of continuous, high-quality resuscitation, including effective chest compressions, positive pressure ventilation, and appropriately timed intravenous doses of adrenaline, the infant remains in persistent asystole with no return of spontaneous circulation.

What is the most appropriate next step in management?

15 / 80

Category: Ethics and Law

A 4-week-old male infant is under ongoing review on the neonatal unit. He was admitted at 2 weeks of age with poor feeding and hypotonia, prompting extensive investigations including whole exome sequencing.

On review, he remains hypotonic with a weak suck reflex. His weight is 3.2 kg (2nd centile) and head circumference is 35 cm (9th centile).

During a private consultation with the mother to discuss the whole exome sequencing results, which confirmed a rare metabolic disorder, an incidental finding of non-paternity was revealed. The mother, visibly distressed, explicitly asks you not to disclose this specific finding to her partner, who is currently at work.

What is the most appropriate immediate action?

16 / 80

Category: Ethics and Law

A male infant, born at 26 weeks gestation, is currently receiving intensive care on the neonatal unit. He has been ventilated since birth for severe respiratory distress syndrome.

Over the past week, his head circumference has rapidly increased, and he has become more irritable with episodes of apnoea. A recent cranial ultrasound scan confirmed a Grade 4 intraventricular haemorrhage with subsequent progressive post-haemorrhagic hydrocephalus.

The neurosurgical team has reviewed him, advising that a ventriculoperitoneal shunt will be required, but they have also communicated that his long-term neurodevelopmental prognosis is extremely poor, with severe disability anticipated. Following a detailed discussion about his condition and future, his parents have stated they do not wish to proceed with shunt surgery and have requested that active life-sustaining treatment be stopped.

What is the most appropriate next action?

17 / 80

Category: Ethics and Law

A 2-month-old male infant is currently managed on the paediatric intensive care unit. He was admitted shortly after birth with severe congenital heart disease and respiratory insufficiency, leading to a confirmed diagnosis of Trisomy 18.

Despite maximal respiratory support for the past six weeks, he remains ventilator-dependent with no realistic prospect of weaning. On examination, he is sedated, intubated, and ventilated, requiring high-frequency oscillatory ventilation and inotropes to maintain perfusion.

His clinical team has had several discussions and concluded that continuing intensive care is futile and burdensome, causing ongoing suffering. However, his parents, citing their deeply held faith, have stated they insist on full medical escalation, including cardiopulmonary resuscitation, should his condition deteriorate further.

What is the most appropriate initial step in the management of this disagreement?

18 / 80

Category: Ethics and Law

A 5-day-old term male infant is currently managed on the neonatal intensive care unit. He was admitted following a severe perinatal hypoxic-ischemic event, leading to a diagnosis of severe Grade 3 Hypoxic-Ischemic Encephalopathy.

On examination, he is profoundly hypotonic with absent primitive reflexes and fixed, dilated pupils. He remains entirely dependent on mechanical ventilation, showing no spontaneous respiratory drive despite minimal sedation.

An MRI of his brain, performed at 72 hours of life, confirmed catastrophic, widespread cerebral injury involving cortical, subcortical, and brainstem structures. After detailed discussions, the treating clinical team and his parents have reached a consensus that continuing intensive care is not in his best interests.

What is the most appropriate next step in management?

19 / 80

Category: Ethics and Law

You are called to the delivery room for a male infant born at 23+4 weeks gestation following an unprecipitated labour. Antenatal counselling regarding periviable birth options was incomplete due to the rapid onset of labour.

At birth, the baby is noted to be limp, with poor respiratory effort. On initial assessment, the baby's heart rate is 80 beats per minute. The parents are at the bedside, visibly distressed and tearfully asking for the team to intervene immediately.

What is the most appropriate immediate action?

20 / 80

Category: Ethics and Law

You are called to the delivery suite to review a primigravida woman in established labour at 22+5 weeks of gestation. Her membranes ruptured 12 hours ago, and cervical dilatation is 6 cm.

The parents have received comprehensive counselling from the senior neonatal team regarding the extremely poor prognosis for an infant born at this gestation. They are united in their decision that they do not wish for active resuscitation to be attempted after birth, clearly requesting a comfort care approach.

The mother is stable, and fetal heart rate monitoring shows a baseline of 140 bpm with good variability.

What is the most appropriate immediate course of action?

21 / 80

Category: Ethics and Law

A 3-year-old boy is awaiting discharge from the paediatric ward. He was admitted 48 hours ago with a viral-induced wheeze, which has now resolved, and is medically fit for discharge.

His observations are stable: HR 98 bpm, RR 22 breaths/min, SpO2 98% on air, and he is alert and interacting. An anonymous telephone call is received at the nursing station alleging that the child's mother has been giving him cocaine to keep him quiet.

What is the most appropriate immediate action?

22 / 80

Category: Ethics and Law

A 6-year-old boy was admitted to the Paediatric Intensive Care Unit two years previously following a sudden, severe respiratory illness. Despite maximal support, his condition deteriorated rapidly, and he sadly died.

His mother, who holds full parental responsibility, has recently submitted a formal written request to the hospital for complete access to her child's entire medical record, including all nursing notes, investigation results, and consultant entries from his admission. She states she needs to understand the full circumstances surrounding his death.

Which of the following statements best describes the legal position regarding this request?

23 / 80

Category: Ethics and Law

A 10-year-old boy attends your paediatric genetics clinic with his parents. He was referred following a 6-month history of subtle motor incoordination and declining school performance.

On examination, he exhibits mild choreiform movements and impaired fine motor skills. His genetic test results have now confirmed a diagnosis of Huntington's Disease.

During the consultation, the genetic test results incidentally reveal that his father, who holds Parental Responsibility, is an asymptomatic and unknowing carrier of the causative gene. The boy's mother then requests that you do not disclose this specific finding about the father to him.

What is the most appropriate next step in this situation?

24 / 80

Category: Ethics and Law

A 17-year-old male attends the paediatric epilepsy outpatient clinic. He is reviewed for poorly controlled tonic-clonic seizures, occurring approximately twice monthly despite optimised polytherapy.

During the consultation, he reveals he is continuing to drive on a regular basis, contrary to previous medical advice given at his last review. Neurological examination is unremarkable.

After a thorough discussion regarding the significant risks to himself and the public, he confirms he understands his legal obligation to inform the Driver and Vehicle Licensing Agency but states he will neither stop driving nor inform them.

What is the most appropriate action?

25 / 80

Category: Ethics and Law

A 10-year-old girl is under your care in the general paediatric clinic. She has been followed up for 18 months due to recurrent non-specific abdominal pain, with recent attendance for symptom exacerbation following parental separation.

You receive a court order requesting the disclosure of her full medical records for a family court proceeding. Her mother, who has parental responsibility, subsequently contacts you and expressly forbids you from releasing the information.

What is the most appropriate immediate action?

26 / 80

Category: Ethics and Law

A 2-year-old boy is an inpatient on the general paediatric ward. He was admitted 24 hours ago with bronchiolitis, requiring oxygen via nasal cannulae.

During the morning ward round at 10:00, you approach his bedside. His mother, present at the bedside, has a strong smell of alcohol on her breath. She appears dishevelled and, when asked about her wellbeing, becomes tearful.

She discloses that she is drinking heavily to cope with a violent partner at home. The child is currently stable, saturating 96% on 0.5 L oxygen, and interacting appropriately.

What is the most appropriate immediate action?

27 / 80

Category: Ethics and Law

You are a Paediatric Registrar completing administrative tasks following a general outpatient clinic. You receive a telephone call from the mother of a 5-year-old girl, who reports she has been sent a clinic letter in error.

The letter contains sensitive clinical information relating to a 4-year-old boy, detailing his recent diagnosis of Crohn's disease, including his faecal calprotectin of 1200 µg/g and ongoing immunosuppressant therapy. The mother confirms she has read the contents, expressing concern about the privacy implications.

What is the most important immediate action?

28 / 80

Category: Ethics and Law

A 4-year-old boy is admitted to the paediatric ward with a 2-day history of fever and lethargy, presenting with a temperature of 38.5 °C, heart rate of 110 bpm, and respiratory rate of 28 breaths/min.

He is the child of a well-known local celebrity. As the Paediatric Registrar responsible for the ward, a nurse hands you a telephone call from a journalist asking for confirmation of the child's admission.

What is the most appropriate response to this enquiry?

29 / 80

Category: Ethics and Law

A 16-year-old boy is recovering on the paediatric surgical ward following an elective minor orthopaedic procedure for which he alone provided valid consent. He is comfortable, mobilising well, and his observations are stable: heart rate 78 bpm, SpO2 98% on air, temperature 37.0 °C.

The foundation doctor receives a telephone call from the patient's parents, who are asking for a detailed update on his condition and recovery progress.

What is the most appropriate immediate action?

30 / 80

Category: Ethics and Law

A 17-year-old girl attends the paediatric infectious disease clinic for a follow-up appointment three months after her recent diagnosis of HIV, identified during a routine sexual health screen. She reports good adherence to antiretroviral therapy and feels well.

On assessment, she is clinically stable and has been thoroughly assessed to have capacity to make decisions about her medical care. She reveals she is in a regular sexual relationship with her 18-year-old partner and, despite extensive counselling on the importance of partner notification and safe sex, she explicitly refuses to inform him of her diagnosis, citing fear of rejection.

What is the most appropriate next step?

31 / 80

Category: Ethics and Law

A 4-year-old girl, Lily, is currently an inpatient on the paediatric ward. She was admitted following concerns from health visitors regarding poor hygiene, missed appointments, and suboptimal weight gain, prompting an upcoming Child Protection Conference.

As the paediatric registrar preparing the medical report, you meet with her father. He appears cooperative and well-groomed.

During the consultation, he discloses in confidence a past history of heroin use, from which he states he is now stable and has been abstinent for three years.

What is the most appropriate action regarding this disclosure for the medical report?

32 / 80

Category: Ethics and Law

A 16-year-old boy was recently treated as a Paediatric Registrar in the A&E. He presented after sustaining a single stab wound to the left anterior abdominal wall following an altercation.

The wound was superficial, approximately 2cm in length, and he remained haemodynamically stable with a heart rate of 82 bpm and blood pressure 115/75 mmHg. After wound care, tetanus prophylaxis, and a period of observation, he was discharged and has just left the department.

A police officer approaches you, explains they are conducting an urgent investigation into a serious assault, and requests the boy's name and address.

What is the most appropriate immediate response?

33 / 80

Category: Ethics and Law

You are the consultant paediatrician in an outpatient clinic, reviewing a 7-year-old boy. He has well-controlled idiopathic generalised epilepsy, diagnosed two years ago, managed with lamotrigine 50 mg twice daily, and has been seizure-free for 18 months.

His school nurse emails, requesting his full management plan, including details of his emergency buccal midazolam, for an upcoming residential trip.

On his last review, he was alert and interactive, with normal neurological examination, including intact cranial nerves and symmetrical tone and power. His growth parameters were tracking the 50th centile for height and weight, and his last lamotrigine level was within therapeutic range.

What is the most appropriate response to this request?

34 / 80

Category: Ethics and Law

You are the consultant paediatrician reviewing an 8-year-old boy in your outpatient clinic, where he attends for well-controlled asthma. His parents are separated, and he lives primarily with his mother.

You receive a written request from his father, who is confirmed to hold Parental Responsibility, for a complete copy of his son's medical records, citing a need for continuity of care during his contact visits. The boy's mother has subsequently contacted your secretary to formally object to this disclosure, stating concerns about the father's motives. The child, while articulate, is not considered to have the capacity to make this complex legal decision himself.

What is the most appropriate course of action?

35 / 80

Category: Ethics and Law

A 15-year-old boy attends a follow-up appointment in the paediatric outpatient clinic for ongoing management of his Crohn's disease. He reports good adherence to medication and improved symptoms, expressing a clear understanding of his condition and treatment plan. He is assessed to have the capacity to make decisions about his medical care.

During the consultation, he explicitly states that he does not want his estranged father, who holds Parental Responsibility, to be informed about the outcome of this appointment. Later that day, the father telephones the department requesting details of the appointment.

What is the most appropriate response?

36 / 80

Category: Ethics and Law

A 15-year-old girl presents to the Emergency Department after disclosing to friends she took a significant paracetamol overdose approximately four hours prior to arrival. She reports feeling generally well but admits to recent emotional distress.

On examination, she is alert and cooperative (GCS 15), with stable vital signs: HR 82 bpm, BP 110/70 mmHg, RR 16/min, SpO2 98% on air.

She is judged to be Gillick competent and consents to treatment with N-acetylcysteine, but explicitly refuses to allow clinical staff to inform her parents, who are currently in the waiting room.

What is the most appropriate immediate action regarding communication with her parents?

37 / 80

Category: Ethics and Law

A 4-year-old boy is reviewed in the general paediatric clinic. He presents with a 2-week history of multiple bruises, predominantly on his lower limbs and torso, which the mother attributes to 'clumsiness'.

On examination, he has several bruises in varying stages of healing, including a 3 cm circular bruise on his left thigh and a linear bruise across his right flank. He is afebrile with a heart rate of 95 bpm and appears otherwise well. During a private conversation, the mother discloses she is a victim of domestic violence perpetrated by the child's stepfather.

What is the most appropriate immediate action concerning this disclosure?

38 / 80

Category: Ethics and Law

A 15-year-old boy presents to the Paediatric Emergency Department after his friend expressed concerns.
During a private consultation, he discloses in confidence a specific, detailed plan to end his life that evening.

On examination, he is alert and cooperative with normal vital signs.
A formal assessment establishes he has the capacity to consent to his own medical treatment.

He explicitly refuses admission and does not consent to his parents being informed of his disclosure.

What is the most appropriate immediate action?

39 / 80

Category: Ethics and Law

A 14-year-old girl attends a routine paediatric outpatient clinic review for asthma. During the consultation, she hesitantly discloses that she has recently started making superficial cuts to her forearms over the past two weeks, using a small razor blade, due to overwhelming school pressure.

On focused examination, several faint, linear, non-bleeding superficial excoriations are noted on her left forearm, none requiring immediate medical intervention. She is visibly distressed, tearful, and avoids eye contact but explicitly denies any current suicidal intent or plans. She pleads with you not to tell her parents, stating she is very frightened of how they will react, fearing punishment and further restrictions.

What is the most appropriate initial action?

40 / 80

Category: Ethics and Law

A 15-year-old boy attends the general paediatric clinic, having made the appointment himself. He presents with anxiety following a recent unprotected sexual encounter and requests a full screening for sexually transmitted infections, explicitly stating he does not want his parents informed.

On examination, he appears well, is articulate, and demonstrates a mature understanding of the risks, benefits, and confidentiality implications of his request. Following a thorough assessment, you are confident he has the capacity to consent to this investigation.

What is the most appropriate course of action?

41 / 80

Category: Ethics and Law

A 7-year-old girl is being cared for on the paediatric intensive care unit. She was admitted three weeks ago with progressive respiratory failure secondary to a severe, irreversible neurodegenerative condition, requiring invasive mechanical ventilation. Her neurological status has deteriorated significantly, and she now exhibits profound multi-organ dysfunction despite maximal support.

The consensus of the multidisciplinary team is that her condition is now terminal, with no prospect of recovery, and further escalation of life-sustaining treatment is not in her best interests. Her parents, however, strongly disagree with this assessment and are requesting the continuation of all possible interventions.

What is the most important initial step in the management of this situation?

42 / 80

Category: Ethics and Law

A 1-year-old male infant is currently managed on the Paediatric Intensive Care Unit. He was admitted following a severe non-accidental head injury, resulting in a catastrophic, irreversible brain injury confirmed by serial neurological assessments over 72 hours.

The clinical team has determined that further life-sustaining treatment, including mechanical ventilation and inotropes, is futile and not in his best interests. His parents are separated, both holding Parental Responsibility.

An irresolvable disagreement has emerged; his mother agrees with the recommendation for withdrawal of treatment, but his father explicitly refuses consent for this to occur.

What is the correct legal and ethical course of action?

43 / 80

Category: Ethics and Law

A 16-year-old girl, admitted to the paediatric ward with severe gastrointestinal bleeding, acutely deteriorates. She is profoundly pale, tachycardic at 130 bpm, tachypnoeic at 32 breaths/min, and hypotensive with a BP of 80/45 mmHg; her haemoglobin is 45 g/L.

She requires an immediate life-saving blood transfusion. Following a comprehensive discussion, she consistently refuses this treatment based on her established religious beliefs. A formal assessment confirms she has the capacity to make this decision, and her parents are present and support her refusal.

What is the most appropriate immediate step in her management?

44 / 80

Category: Ethics and Law

A 9-year-old boy with severe cerebral palsy is admitted to the hospice for end-of-life care, having experienced recurrent aspiration pneumonias despite optimal positioning. He is fed exclusively via a percutaneous endoscopic gastrostomy tube as he has no safe swallow, receiving 200 ml of feed every four hours.

His parents inform the clinical team that he appears to be in significant distress during the administration of feeds, exhibiting marked grimacing, arching, and increased spasticity, and ask for them to be stopped. On examination, he is euvolaemic with stable vital signs and no signs of fluid overload.

What is the primary ethical justification for considering the withdrawal of his artificial nutrition?

45 / 80

Category: Ethics and Law

A 4-year-old boy presents to the Emergency Department. He has a severe neurodisability with a history of recurrent respiratory infections and is brought in by ambulance with acute respiratory distress, developing rapidly over 30 minutes after a meal.

On examination, he is agitated with widespread urticaria across his trunk and limbs, and audible stridor. His respiratory rate is 45 breaths/minute, oxygen saturations are 88% on air, and he has a weak, thready radial pulse of 160 bpm.

An Advance Care Plan is in place, stating he is for ward-based care and should not be intubated for respiratory failure secondary to his underlying condition.

What is the most appropriate immediate action?

46 / 80

Category: Ethics and Law

An 11-year-old boy is an inpatient on a tertiary paediatric cardiology ward. He has known end-stage dilated cardiomyopathy and is active on the heart transplant list.

Over the past 24 hours, his clinical condition has deteriorated significantly, with increasing respiratory distress and poor perfusion. The medical team proposes a Ventricular Assist Device (VAD) as a bridge to transplantation.

Following a full discussion, the child, who is assessed to be competent, and his parents jointly decline this intervention. They express a clear and unified wish to be discharged home for palliative care, prioritising comfort.

What is the most appropriate course of action?

47 / 80

Category: Ethics and Law

A 14-year-old girl with relapsed acute myeloid leukaemia is receiving end-of-life care on the paediatric oncology ward. Over the last 24 hours, she has developed worsening intractable respiratory distress, with a respiratory rate of 40 breaths/min and oxygen saturations dropping to 88% on 10 L oxygen via a non-rebreather mask.

She appears agitated, grimacing, and rates her pain as 9/10 despite regular oral morphine. Her consultant plans to administer an escalating dose of intravenous diamorphine and midazolam. The primary intention is to relieve her suffering, accepting that a secondary effect may be to hasten her death.

Which ethical principle most accurately describes this clinical decision?

48 / 80

Category: Ethics and Law

A 15-year-old boy is an inpatient on the paediatric haematology ward. He was diagnosed with Acute Myeloid Leukaemia six months ago and has recently completed his second cycle of induction chemotherapy, achieving remission.

The multidisciplinary team recommends an allogeneic bone marrow transplant due to his high-risk disease profile. Following extensive discussions about the procedure's risks and benefits, he is assessed as Gillick competent and provides his explicit consent for the transplant. However, his parents, who both hold parental responsibility, refuse to authorise the treatment, citing significant concerns about potential adverse effects and the impact on his future quality of life.

Which of the following statements most accurately describes the legal position regarding the proposed treatment?

49 / 80

Category: Ethics and Law

A male infant is born on the labour ward. The delivery was complicated by extreme prematurity, with a confirmed gestation of 22 weeks and 5 days.

Extensive antenatal discussions regarding the exceptionally poor prognosis and high morbidity risk for infants born at this gestation had taken place with the parents, aligning with national guidance from the British Association of Perinatal Medicine (BAPM).

At birth, the infant is limp, pale, and shows no spontaneous respiratory effort, despite tactile stimulation. Following a joint decision with the parents to withhold active resuscitation, comfort care is initiated. This approach considers the significant burden of intensive care interventions against the minimal chance of a favourable outcome.

Which of the following ethical principles is the primary justification for this clinical approach?

50 / 80

Category: Ethics and Law

A 17-year-old girl is an inpatient on a paediatric ward, admitted for refeeding and management of severe anorexia nervosa. She has been on the ward for three weeks, showing limited weight gain and persistent food refusal.

Routine morning blood tests indicate a serum potassium of 2.1 mmol/L. The medical team recommends urgent intravenous potassium replacement to mitigate the high risk of cardiac arrhythmia.

The patient adamantly refuses this treatment, stating she feels well. Following a formal multidisciplinary assessment, she is deemed to lack capacity for this specific decision due to the profound influence of her eating disorder on her perception of risk and need for treatment. Her parents are present and supportive of medical intervention.

What is the primary legal basis for administering treatment against her wishes?

51 / 80

Category: Ethics and Law

A 2-year-old girl is admitted to the Paediatric Intensive Care Unit following a severe hypoxic-ischaemic brain injury sustained after a prolonged out-of-hospital cardiac arrest. Despite maximal support, her neurological status has progressively deteriorated over the past 72 hours.

On examination, she is unresponsive with fixed, dilated pupils. Formal brainstem testing, meticulously conducted by two senior clinicians in accordance with national guidelines, unequivocally confirms the irreversible cessation of all brainstem function.

Her parents, however, are struggling to accept this diagnosis and are adamant that mechanical ventilation must continue.

What is the correct legal and medical position regarding further management?

52 / 80

Category: Ethics and Law

A 6-year-old boy is reviewed on the paediatric oncology ward. He has acute lymphoblastic leukaemia and has recently experienced a third relapse, presenting with increasing fatigue and bone pain over the last two weeks.

On examination, he is pale and lethargic but interactive.

His parents have been counselled by the haematology team that further intensive chemotherapy is not curative and is anticipated to prolong his life by only a matter of weeks, with significant side effects. They have declined this offer, stating a clear wish to stop all active treatment and focus on his quality of life at home.

What is the most appropriate next step in his management?

53 / 80

Category: Ethics and Law

A 15-year-old boy with known Duchenne muscular dystrophy attends a multidisciplinary clinic with his parents. They report a significant decline in his respiratory function over the past year, with increasing fatigue limiting his mobility and school attendance.

He now requires nocturnal non-invasive ventilation for 10 hours nightly. On examination, he is thin, with a weak cough and reduced chest expansion.

His forced vital capacity has decreased from 45% to 30% predicted in the last 12 months. The team initiates a discussion to formulate an Advance Care Plan with the family.

What is the primary objective of this planning process?

54 / 80

Category: Ethics and Law

A 10-year-old girl with severe neurological disability and intractable epilepsy is admitted to the paediatric ward with aspiration pneumonia. A formal Advance Care Plan, created in agreement with her parents, explicitly states that admission to the Paediatric Intensive Care Unit is to be avoided.

During her admission, she develops increasing respiratory distress, with a respiratory rate of 45 breaths/min, heart rate 130 bpm, and oxygen saturations of 88% on 4 L oxygen via nasal cannula. She is drowsy with grunting respirations and significant subcostal recession.

What is the most appropriate next step in her management?

55 / 80

Category: Ethics and Law

A 3-month-old female infant is being cared for on the paediatric intensive care unit. She was admitted shortly after birth due to severe respiratory distress and has a confirmed diagnosis of Trisomy 18.

She has associated severe cardiac defects, including a large ventricular septal defect and pulmonary atresia, and has been ventilator-dependent since admission. Despite multiple attempts over the past six weeks, including various ventilation modes and pharmacological support, it has not been possible to wean her from mechanical ventilation.

She remains tachycardic at 160 bpm, saturating 88% on 100% oxygen, and requires inotropic support. The multidisciplinary team and her parents have reached a consensus that further intensive care is futile and overly burdensome, offering no prospect of meaningful recovery.

What is the primary legal principle guiding the decision to withdraw life-sustaining treatment in this case?

56 / 80

Category: Ethics and Law

A 14-year-old girl with metastatic osteosarcoma is an inpatient on the paediatric oncology ward, experiencing progressive disease with increasing pain and fatigue. She appears cachectic and has mild dyspnoea at rest (respiratory rate 22 breaths/min, SpO2 94% on air).

She has been formally assessed as Gillick competent and articulates a clear understanding of her prognosis, consistently expressing a wish for a Do Not Attempt Cardiopulmonary Resuscitation (DNACPR) order. Her parents, who are also present, are adamant that they do not consent to this.

What is the most appropriate initial action?

57 / 80

Category: Ethics and Law

A 16-year-old boy with end-stage cystic fibrosis is reviewed on the respiratory ward. He has experienced increasing respiratory exacerbations requiring frequent hospital admissions over the past six months, with declining lung function and poor quality of life.

He has been assessed by the multi-disciplinary team, including a consultant psychiatrist, as having full capacity to make decisions about his medical treatment. On examination, he is cachectic, with clubbing and a persistent cough, but is alert and oriented.

He has articulated a clear and consistent wish to decline further life-sustaining therapies, including intravenous antibiotics for his current Pseudomonas aeruginosa infection, and to be referred for palliative care in a hospice. His parents do not support his decision and are requesting that active treatment continues, believing he still has a chance for recovery.

Which of the following statements best describes the legal framework governing this situation?

58 / 80

Category: Ethics and Law

An 8-year-old boy is an inpatient on a paediatric oncology ward, receiving management for relapsed and refractory acute lymphoblastic leukaemia. Following the failure of second-line chemotherapy, including a stem cell transplant, the multidisciplinary team has concluded that no further curative options exist and recommends a transition to palliative care.

The child is increasingly fatigued, with persistent nausea and poor oral intake. His parents, however, are requesting a third-line experimental chemotherapy protocol, citing online research.

The clinical team has determined this treatment would be futile, causing significant suffering without realistic prospect of benefit. Despite repeated discussions and attempts at mediation with the family, the conflict over the child's best interests remains irreconcilable.

What is the most appropriate definitive step to resolve this impasse?

59 / 80

Category: Ethics and Law

A 12-year-old boy with known Duchenne muscular dystrophy is admitted to the paediatric high dependency unit presenting with increasing dyspnoea over 24 hours. He is using accessory muscles of respiration, has a weak cough, and his SpO2 is 88% on 4 L oxygen with a pCO2 of 8.2 kPa, indicating impending respiratory failure. The clinical team recommends commencing non-invasive ventilation.

Following a thorough discussion of the benefits and burdens, he is assessed to be Gillick competent and consistently expresses a clear wish to decline this treatment. His parents, who are present, are adamant that he should receive ventilation.

What is the most appropriate immediate legal step?

60 / 80

Category: Ethics and Law

A 5-year-old boy is currently managed on the Paediatric Intensive Care Unit. He was admitted two weeks ago following a severe hypoxic-ischaemic brain injury secondary to a drowning incident. Neurological assessments, including serial clinical examinations, have established that there is no prospect of recovery, with absent brainstem reflexes and a Glasgow Coma Scale score of 3.

He remains ventilator-dependent and requires ongoing inotropic support. Following multiple sensitive discussions, the treating clinicians and his parents agree that continued mechanical ventilation is not in his best interests, and they wish to focus on comfort.

What is the most appropriate next step in his management?

61 / 80

Category: Ethics and Law

A 14-year-old girl is admitted to the paediatric high dependency unit. She presents with a 6-hour history of severe haematemesis and melaena, indicative of a severe gastrointestinal haemorrhage.

On assessment, she is pale, clammy, tachycardic (heart rate 130 bpm), and hypotensive (blood pressure 75/40 mmHg). You assess her to be Gillick competent, and both she and her parents, who are Jehovah's Witnesses, consistently refuse the administration of blood products.

An urgent full blood count reveals a haemoglobin of 50 g/L. Despite initial fluid resuscitation with 40 mL/kg crystalloid, her clinical condition is deteriorating, with worsening tachycardia and reduced conscious level.

What is the most appropriate immediate legal step to take?

62 / 80

Category: Ethics and Law

A 3-year-old boy is admitted to the paediatric surgical ward for a planned tonsillectomy due to recurrent tonsillitis, experiencing seven episodes in the last year. His mother, the primary carer, provided informed written consent for the procedure during the pre-assessment clinic.

On the day of surgery, the boy is afebrile with stable vital signs; examination reveals hypertrophied tonsils but no acute inflammation. Suddenly, the boy's biological father, who was not married to the mother and is not named on the 2021 birth certificate, arrives and formally objects to the surgery proceeding.

Which of the following statements most accurately describes the father's legal position regarding this clinical decision?

63 / 80

Category: Ethics and Law

An 11-year-old boy with known cystic fibrosis attends his routine specialist clinic review. He is being considered for a novel gene therapy research study, which necessitates an additional diagnostic bronchoscopy, a procedure carrying recognised risks including pneumothorax and infection.

On discussion, the child articulates a clear comprehension of the trial's aims and potential benefits, expressing strong enthusiasm to participate. However, his parents voice significant reservations regarding the invasive nature of the procedure and potential long-term unknowns.

What is the minimum legal requirement for this child to be enrolled in the study?

64 / 80

Category: Ethics and Law

A 7-year-old boy is on the paediatric day unit for a planned investigation. He requires a necessary blood test to monitor his chronic condition, for which his mother has provided appropriate written consent following a detailed discussion.

This is his third venepuncture in six months. As the doctor approaches the bedside to perform the venepuncture, the child becomes visibly distressed, begins to cry, and pulls his arm away, shouting "No!". He is otherwise afebrile and alert.

What is the most appropriate initial management step?

65 / 80

Category: Ethics and Law

A 16-year-old boy attends a surgical pre-assessment clinic for an elective orchidopexy for an undescended testis. He reports no pain but is keen to proceed with the surgery after understanding the long-term benefits and risks.

On assessment, he is articulate and mature, demonstrating full capacity to understand the proposed treatment, including potential complications. He provides his informed consent to proceed.

Subsequently, his parents, who hold Parental Responsibility, contact the clinical team to state their strong objection and formally forbid the procedure.

Which of the following statements best describes the legal position regarding consent in this situation?

66 / 80

Category: Ethics and Law

A 15-year-old boy with Type 1 Diabetes is an inpatient on the paediatric ward. He was admitted 24 hours ago with diabetic ketoacidosis and is now recovering well.

During the evening medication round, he verbally refuses his scheduled subcutaneous insulin injection. He is alert and cooperative, with stable vital signs and a current capillary blood glucose of 10.5 mmol/L.

He has previously been assessed as Gillick competent. His parents, present at the bedside, insist you administer the treatment against his wishes, stating it is in his best interests.

What is the most appropriate immediate action?

67 / 80

Category: Ethics and Law

An 8-year-old boy is brought to the emergency department by ambulance following a high-speed road traffic collision, having been found unresponsive at the scene. He arrives without identification or accompanying relatives, and attempts to contact next of kin are ongoing.

On arrival, he is unconscious with a GCS of 6/15, pupils are unequal (left 6mm fixed, right 3mm reactive), and he is tachycardic at 130 bpm with shallow breathing. An urgent computed tomography scan of his head demonstrates an extradural haematoma, requiring immediate life-saving neurosurgical intervention.

What is the most appropriate legal basis for proceeding with the operation?

68 / 80

Category: Ethics and Law

A 7-year-old boy attends a community paediatric clinic for a routine Looked After Child (LAC) health assessment. He has been living with his designated foster carers for six months under an Interim Care Order and is due for his scheduled booster immunisations, including DTaP/IPV and MMR.

The foster carers have provided written consent for these vaccinations. On examination, he is well, afebrile (36.8 °C), alert, and thriving, with no acute concerns.

His biological parents, who retain concurrent Parental Responsibility, have formally communicated their strong opposition to any immunisations via their solicitor.

Considering the legal framework, which of the following holds the ultimate legal authority to provide consent for these scheduled immunisations?

69 / 80

Category: Ethics and Law

A 13-year-old girl attends a routine paediatric gastroenterology outpatient appointment. She has stable Crohn's disease, diagnosed two years ago, currently managed on mesalazine with no recent flare-ups or hospital admissions.

Her growth is tracking the 50th centile, and she reports good energy levels. On examination, she is afebrile, heart rate 78 bpm, blood pressure 105/65 mmHg, and her abdomen is soft and non-tender.

Her consultant proposes initiating a new biologic medication to reduce the risk of future flare-ups, discussing its mechanism, potential side effects, administration, and alternative strategies. The patient articulates clearly that she does not wish to start the new therapy.

In determining whether she has the capacity to refuse this non-urgent treatment, which of the following is the most important factor?

70 / 80

Category: Ethics and Law

A 17-year-old boy presents to the Emergency Department with a 24-hour history of peri-umbilical pain migrating to the right iliac fossa, associated with anorexia and a single episode of vomiting. On examination, he is afebrile (37.2 °C), heart rate 88 bpm, blood pressure 110/70 mmHg, with localised tenderness and guarding in the right iliac fossa.

A surgical registrar reviews him, diagnoses acute appendicitis requiring an emergency appendicectomy, and explains the procedure, significant risks, and alternatives. The registrar concludes the patient has the capacity to make an informed decision, and he provides clear verbal and written consent to proceed.

His parents are travelling abroad and cannot be contacted.

What is the most appropriate next step?

71 / 80

Category: Ethics and Law

A 14-year-old boy presents to the Paediatric Emergency Department accompanied by his older sister, reporting a two-month history of anhedonia and poor sleep. For several weeks, he has been hearing distinct male voices commanding him to end his life and confirms he has a specific plan to do so, detailing method and timing.

On mental state examination, he is cooperative, maintains eye contact, and articulates his thoughts clearly, demonstrating a good understanding of the risks. He is assessed as having capacity to make decisions regarding his care but explicitly requests that his parents are not informed.

His physical examination is unremarkable, and observations are stable.

What is the most appropriate immediate action?

72 / 80

Category: Ethics and Law

A 15-year-old girl attends a community sexual health clinic. She presents requesting oral contraception, stating she has been in a stable, consensual relationship with her 16-year-old boyfriend for six months. She is sexually active and concerned about pregnancy.

On focused assessment, she demonstrates a clear understanding of contraception, risks of pregnancy, STIs, and confidentiality. Her vital signs are stable: HR 78 bpm, BP 110/70 mmHg, SpO2 99% on air. She explicitly refuses to allow her parents to be informed.

What is the most appropriate next step in her management?

73 / 80

Category: Ethics and Law

A 12-year-old boy with known severe cerebral palsy attends his routine neurodisability clinic review. His parents report ongoing difficulties with oral feeding, recurrent chest infections, and poor weight gain despite dietary modifications over the past six months.

He has profound global developmental delay, is non-verbal, and demonstrates no purposeful communication. Clinical examination confirms significant dystonia and poor bulbar control, with a weight below the 0.4th centile.

The multidisciplinary team recommends a gastrostomy insertion to manage his nutritional needs and reduce aspiration risk. His parents, who hold parental responsibility, are in full agreement with the plan.

What is the primary legal basis for proceeding with this procedure?

74 / 80

Category: Ethics and Law

A 5-year-old boy presents to the pre-assessment clinic for an elective tonsillectomy due to recurrent tonsillitis, experiencing 7 episodes in the last year, impacting school attendance.

His parents are separated, both holding Parental Responsibility. His mother provided valid written consent for the operation during the pre-assessment.

However, prior to the day of surgery, his father contacts the Paediatric Registrar, explicitly stating he formally objects to the procedure taking place, citing concerns about surgical risks.

What is the most appropriate next step in management?

75 / 80

Category: Ethics and Law

A 14-year-old boy attends the orthopaedic outpatient clinic. He presents with persistent right knee pain and mechanical symptoms for 18 months, significantly impacting his mobility and school sports. Following extensive physiotherapy and non-surgical management, an elective arthroscopic debridement is planned.

On assessment, he demonstrates a comprehensive understanding of the procedure, its risks, and potential benefits, and is formally assessed as Gillick competent, giving his clear consent for the operation. However, his parents, who both hold Parental Responsibility, explicitly refuse to provide their consent, stating they wish for him to try alternative herbal therapies first.

Regarding the legal authority to proceed with the elective surgery, what is the most accurate statement?

76 / 80

Category: Ethics and Law

A 10-year-old boy attends the paediatric research unit with his parents. He has been identified as a potential participant for a non-therapeutic observational study investigating sleep patterns in healthy children, requiring weekly saliva samples over three months.

His parents have received a comprehensive patient information leaflet and, after a detailed discussion with the research nurse, provide written informed consent for his participation. However, when the study protocol, including the collection of saliva samples, is explained directly to the boy, he firmly states, "I don't want to do it, I hate spitting."

He appears alert and articulate, making eye contact.

What is the most appropriate next step for the research team?

77 / 80

Category: Ethics and Law

A 2-year-old girl is brought to the Emergency Department following a significant traumatic injury. She sustained a fall from a height 30 minutes prior and is rapidly deteriorating.

On examination, she is pale, with cool peripheries, a capillary refill time of 5 seconds, a heart rate of 160 bpm, and a blood pressure of 60/40 mmHg, with clinical signs of severe haemorrhagic shock. You determine that an immediate blood transfusion is required to save her life, but her parents refuse to provide consent on religious grounds.

What is the most appropriate immediate action?

78 / 80

Category: Ethics and Law

A 16-year-old boy is admitted to the paediatric oncology ward with relapsed leukaemia. He presents with increasing fatigue and new bruising over the past two weeks.

On examination, he is pale with scattered petechiae; his spleen is palpable 3 cm below the costal margin. His latest full blood count shows Hb 78 g/L, WCC 2.1 x 10^9/L, platelets 35 x 10^9/L.

He has been counselled regarding a new chemotherapy protocol, which offers potential curative benefits but carries significant side effects. He is assessed by the clinical team and deemed to have the capacity to make decisions about his treatment.

Despite understanding the implications, he refuses the intervention, explaining he cannot tolerate the severe nausea and mucositis he experienced previously.

His parents strongly disagree, insisting treatment proceeds. The responsible clinical team also believes treatment is in his best interests.

What is the most appropriate legal course of action?

79 / 80

Category: Ethics and Law

A 15-year-old boy attends your community sexual health clinic. He presents requesting screening for chlamydia, stating he had unprotected intercourse with a new partner two weeks ago.

He appears calm and articulate, clearly explaining the screening process and potential implications of a positive result. On focused review, he denies any dysuria, discharge, or abdominal pain.

He is afebrile, alert, and cooperative, with no signs of distress or coercion. He explicitly states he does not want his parents informed, expressing concern about their reaction.

What is the most appropriate immediate course of action?

80 / 80

Category: Ethics and Law

A 14-year-old girl attends the paediatric gynaecology clinic with her mother. She reports heavy, prolonged menstrual bleeding for the past six months, requiring frequent pad changes and causing significant fatigue.

Her haemoglobin is 105 g/L. After a thorough discussion, a pelvic examination is recommended to investigate the menorrhagia.

The 14-year-old girl indicates she understands the rationale for the procedure but clearly refuses to undergo it. Her mother provides verbal consent for the examination to proceed, stating, "She is just being shy."

What is the most appropriate immediate action?

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